[1][2] It begins south of Welkom at an off-ramp junction with the R30 road (which takes over as the ZR Mahabane Highway to Bloemfontein) and ends east of Odendaalsrus at a t-junction with the R34 road (which takes over as the ZR Mahabane Highway to Kroonstad).

It heads south into Welkom as a dual carriageway and after 5 kilometres, it meets the R70 road at a 4-way junction.

After another 2 kilometres, as the dual carriageway proceeds southwards towards Welkom Central, the R730 becomes the road to the south-south-east towards Thabong.

It passes through Thabong southwards for 3.5 kilometres (with one off-ramp junction) before reaching an intersection with the R73 road coming from the centre of Welkom.

The R730 continues for another 22 kilometres south-south-west, crossing the Sand River (where it becomes a single carriageway, still with 2 lanes in each direction), to reach its southern terminus where it meets the R30 road south of Welkom (south-west of Virginia).