969376089ENSG00000109756ENSMUSG00000062232Q9Y4G8Q8CHG7NM_001351728NM_001394067NM_001099624NM_001310536NP_001338657NP_001093094NP_001297465Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

[5][6][7] RAPGEF2 is a cyclic AMP binding protein.

[8][9] Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states.

Guanine nucleotide exchange factors (GEFs) such as RAPGEF2 serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.

[6] RAPGEF2 has been shown to interact with RAP1A[6] and RALGDS.