[5][6][7] RAS guanyl nucleotide-releasing protein (RASGRP) is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain.

It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation.

Since dyneins are motor proteins, their function is to circulate the elements inside the cells.

Dr. Orange's laboratory studies have established a functional link between the defects of natural killer cells and dyneins, which in combination with Other observations led doctors to try the drug lenalidommide to treat the patient.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.