The RE80 is a RegioExpress service that runs every half-hour between Locarno and Chiasso in the Swiss canton of Ticino, with every other train continuing to Milano Centrale in Milan, Italy.

The service is operated by Treni Regionali Ticino Lombardia (TILO), a joint venture between the Swiss Federal Railways and Trenord.

South of Chiasso, every other train continues to Milano Centrale in Italy, providing hourly service between there and Locarno.

The RE80 began operation on 13 December 2020, running hourly from Locarno to Lugano with limited service beyond to Mendrisio or Chiasso.

This timetable was only temporary, and beginning on 5 April 2021 the RE80 began running half-hourly to Chiasso and hourly to Milano Centrale, replacing the RE10.