The station is served by the long-distance trains that cross the Gotthard, together with S10 and S40 of the Ticino regional network, and line S11 of the Milan suburban service.

[5] Thanks to numerous complaints raised by various sectors of the political and institutional elements of Ticino[citation needed], Swiss-Italian EuroCity services returned to Chiasso.

[4] The opening of the Ceneri Base Tunnel in December 2020 reduced travel times from Chiasso to Bellinzona by 20 minutes and led to an increase in EuroCity services to Milano.

The traction voltages, motors and signalling systems of the two networks are different, and therefore trains passing through the station must change locomotives.

The yard tracks are also required to be divided into two parts, connected to the station's central platform by a corridor, where there are also customs offices.