The story takes place immediately after the events of the first film[4] and follows a team of soldiers assigned to protect a scientist supposedly sent to investigate the cause of the outbreak, but who may already know more about it than he claims.

Dr. Owen (Jonathan Mellor), an official from the Ministry of Health, and a heavily armed GEO team of four (Fernandez, Martos, Rosso and Larra) equipped with video cameras and body cams are sent into a quarantined apartment building to find out what happened to its inhabitants, who have been rendered infectious and violent by a contagious virus.

He reveals that he is actually a priest sent by the Vatican to get a blood sample from a possessed girl named Tristana Medeiros, the root of the infection.

After Tito is infected, the crew locks Mire and Ori in a room and encounter reporter Ángela Vidal (Manuela Velasco), shocked but safe.

The group questions the possessed Tito and deduce from his cryptic answers that Medeiros is in the penthouse and certain areas are only accessible in total darkness and infrared light.

She tells them that the mission has been accomplished, that Owen must stay inside due to being infected, and that the only survivor allowed to leave is Ángela.

A flashback reveals what happened right before the film's beginning: Ángela was captured by Medeiros and had a vermiform organism orally transmitted into her.

[15] In March 2010 Magnolia Pictures acquired the rights for the US market[16] and will screen the film in a theatrical release in July 2010.

The site's consensus states: "It lacks the surprising jolt of the first installment, but [REC] 2 almost maintains the original's chilling momentum – and proves not all horror sequels were made equal".

[25] Empire also awarded the film 4 stars, saying: "Here’s a horror juddering with such in-your-face malevolent energy, it’s like being caught in a first-person shooter possessed by the devil".

"[28] Genesis was released on 30 March 2012, and centers on an outbreak in a distant location from the original apartment building, also having prequel elements.