RKSV Nuenen started playing in the Vierde Klasse of the Royal Dutch Football Association in 1948.

During the next years it played stable at usually competing for the top spots of the Eerste Klasse, also after parting ways with Jan Poortvliet in 2007.

[6] In 2011 RKSV won the section championship of the Eerste Klasse and the club promoted for the second time to the Hoofdklasse.

[7] At the start of 2014 Eric Clijk became the new coach of Nuemen after it had fired Willy Scheepers on 11 November 2013.

[11][12] Nuenen completed this season as champion of the Eerste divisie and promoted to the Hoofdklasse for the third time in its history.

For 2017–2018 it is strengthened by defender Tim Rerimassie, who joined from Helmond Sport and had played some of his youth at RKSV.

[19][20] Davy Heesakkers, another former RKSV player, started coaching the women's squad in the summer of 2017.