The team's origins began with the Sepang Racing Team (SRT) under ownership by the Sepang International Circuit and managed by circuit CEO Razlan Razali and former racers Johan Stigefelt and Wilco Zeelenberg.

[4] On 30 October, RNF announced that Stigefelt would split from the team under "mutual agreement".

[5] The team continued in 2022 under a number of SRT's previous agreements, with Italian rider Andrea Dovizioso on a factory-specification Yamaha YZR-M1.

[7] Naming rights for the team were secured by Italian energy and telecommunications brand WithU in early 2022, and the team raced under the name WithU Yamaha RNF MotoGP Racing.

[10][11] Riders Miguel Oliveira and Raúl Fernández joined from the KTM stable.