In contrast, the nonselective monoamine transporter inhibitor RTI-112 had a slower rate of onset (30–60 min) and a longer duration of action (10h).

"[3] The efficacy of cocaine analogs to elicit self-administration is related to the rate at which they are administered.

[4] Nonselective analogs are less likely to function as "reinforcers" than reuptake inhibitors that have DAT specificity.

[3] In order for a dopamine reuptake inhibitor (DRI) such as cocaine to induce euphoria, PET scans on primates reveal that the DAT occupancy needs to be >60%.

[2] A significantly higher dose was required to get >70% DAT occupancy in the case of RTI-112;[2] however, RTI-112 was still able to suppress cocaine administration at the ED50, suggesting a serotonergic mechanism was responsible for this.