RTI(-4229)-113 (2β-carbophenoxy-3β-(4-chlorophenyl)tropane) is a stimulant drug which acts as a potent and fully selective dopamine reuptake inhibitor (DRI).

[2] RTI-113 has also been tested against cocaine in self-administration studies for DAT occupancy by PET on awake rhesus monkeys.

[4][5] In order for a DRI such as cocaine to induce euphoria PET scans on primates reveal that the DAT occupancy needs to be >60%.

[3] Whereas cocaine is a fast acting rapidly metabolized DRI, RTI-113 has a longer duration span.

[10] With regard to amphetamine, a recent paper disputes this claim, and makes the point that the role of NE is completely underrated.