[1][2] Khanna has starred in a number of commercially successful films such as Bengal Tiger (2015), Supreme (2016), Jai Lava Kusa (2017), Tholi Prema (2018), Imaikkaa Nodigal (2018), Venky Mama (2019), Prati Roju Pandage (2019), Thiruchitrambalam (2022), Sardar (2022) and Aranmanai 4 (2024) that established her as one of the leading actresses in Telugu and Tamil cinema.

[citation needed] Impressed with her performance in Madras Cafe, actor Srinivas Avasarala approached her for the female lead role in his directorial debut Oohalu Gusagusalade, which also featured himself and Naga Shaurya in the lead roles,[14] which she signed in late October 2013 after considering many other south films, adding that the scope of performing made her sign the film.

[15] Khanna initially felt that it would be more of a dancing role with little scope for acting when approached for narration, but found her character practically in every scene in the film.

[14] She called her character Prabhavati as a grey, stubborn, arrogant girl but in a lovable way, which she claimed to be very different from what she was in real life except for the fact that she hails from Delhi.

[16] Khanna confirmed in early April 2014 that she appeared in a small role in the Telugu film Manam,[17] which had its theatrical release before Oohalu Gusagusalade.

Sangeetha Devi Dundoo of The Hindu called her an "actor with potential",[19] while Hemanth Kumar of The Times of India stated that she gave a "commendable" performance which helped the movie to some extent.

[21] Her next Telugu film was Joru, directed by Kumar Nagendra opposite Sundeep Kishan, which she signed after Madras Cafe and while shooting for Oohalu Gusagusalade.

[22] Sangeetha Devi Dundoo of The Hindu stated that she provides solace along with Kishan, Brahmanandam and Saptagiri in a film which was "let down by incoherent writing and amateurish execution".

[24] Khanna's next was Jil, directed by Radha Krishna Kumar opposite Gopichand,[25] which she signed in early July 2014 after the makers approached her considering her performance in Oohalu Gusagusalade.

[citation needed] In 2016, her first release was Supreme, in which she starred alongside Sai Dharam Tej, and was a commercial success,[30] with critics praising her comic-timing in her performance as Bellam Sridevi, a cop who gets into hilarious situations.

[31] Her next release was Hyper, opposite Ram Pothineni for the second time which opened to mixed reviews and was an average grosser at the box office.

[32] In 2017, her first release was Jai Lava Kusa, opposite N. T. Rama Rao Jr. which opened to positive reviews and became a box office hit by grossing more than ₹100 crore.

[34] Her last release of 2017 was Oxygen, marking her second collaboration with Gopichand, opening to mixed reviews and the movie went on to be an average grosser at the box office.

[36] Her next release was Srinivasa Kalyanam, opposite Nithiin, directed by National Award winner Satish Vegesna which opened to mixed reviews but the chemistry between the lead pair was appreciated.

Her next release was a multi-starrer Imaikkaa Nodigal, marking her debut in Tamil cinema opening to highly positive reviews with critics praising her performance as a girl-next-door character and was commercially successful at box office.

[37] Her next release in Tamil was Adanga Maru, opposite Jayam Ravi which received positive reviews from the critics[38] and became a commercial success at the box office.

[39] In 2019, Her first release was Ayogya opposite Vishal, which was an official remake of the 2015 Telugu hit, Temper which received generally positive reviews from audience and critics.

In December 2019, She had two releases, Venky Mama opposite Naga Chaitanya and Venkatesh which received mixed reviews and Prati Roju Pandage marking her second collaboration with Sai Dharam Tej, which received generally positive reviews with critics praising her comic-timing in her performance as "Angel" Aarna, a highly self-obsessed girl from the village town, Rajahmundry.

[88] As of February 2025[update], Khanna has completed shooting for Hindi film TME alongside her The Sabarmati Report co-star Vikrant Massey.

She also launched an NGO called "Roti Bank" foundation, where she tied up with several NGOs that cater to the different needs and issues facing people during the COVID-19 pandemic in India.