She then made the transition to Hollywood, appearing in films including Man-Thing (2005), See No Evil (2006), Transformers (2007), Bottle Shock (2008), Shutter (2008), Cedar Boys (2009), Splinterheads (2009), Red Dog (2011), The Darkest Hour (2011) and Any Questions for Ben?

She starred in Marvel Cinematic Universe streaming superhero television series Jessica Jones (2015–2019), Luke Cage (2016), and The Defenders (2017) as Trish Walker.

Her most prominent role to date was as Maggie Madsen, a signals analyst, in the 2007 Transformers, where she appeared alongside Megan Fox and Shia LaBeouf.

[5] In 2008, Taylor scored a starring role in the US horror-thriller Shutter, a remake of the 2004 Thai film of the same name opposite Joshua Jackson.

Taylor began a recurring role on Grey's Anatomy as Dr. Lucy Fields, an obstetrician and maternal-fetal fellow.

[14] Taylor had a key supporting role in the 2012 Australian comedy Any Questions for Ben?, created by Working Dog Productions.

[19] In 2014, Taylor played a supporting role in the thriller The Loft, a remake of the 2008 original, alongside fellow Australian Isabel Lucas.

[24] In 2019, Taylor appeared in Finding Steve McQueen as Molly Murphy, where she starred alongside Travis Fimmel, Forest Whitaker, and William Fichtner.