Also, the river valley is the natural route for the major road in Western North Macedonia which connects the regions of Polog and Ohrid.

It flows westwards, on the northern section of the mountain of Ničipurska planina (Brodec peak, still part of the Šar massif) and for several kilometers forms the Kosovo-Macedonian border.

After it receives the Crni Kamen from the right and another stream coming from Kosovo, the Kafa Kadis turns south into the Macedonian proper again and from this point it is known as the Radika.

There are many interesting places along the Radika valley; including the villages of Velebrdo, Rostuša, Janče, Prisojnica, Skudrinje, the Saint Jovan Bigorski Monastery, the spa of Kosovratska banja (with sulphuric water, hot up to 49 °C or 120 °F) and the unique Alčija cave, formed in alabaster.

It has been designated an Important Bird Area (IBA) by BirdLife International because it supports populations of Eurasian eagle-owls, golden eagles, yellow-billed choughs, wallcreepers, alpine accentors and white-winged snowfinches.