It was founded on 25 March 2020 by a group of professors, directors and PhD students in response to social isolation protocols imposed as a result of the COVID-19 pandemic.

[7] On May Day, Radio Quarantine held a collaboration with the Udichi Shilpi Goshti, the largest cultural organisation in Bangladesh; the station hosted a show featuring revolutionary songs and commemorated the 1886 Haymarket massacre by chronicling its history.

Kasturi Basu, one of the administrators, states that the idea for collaborating with Bangladeshi individuals on May Day had come about during their planning of shows for the birth anniversary of Rabindranath Tagore on 7 May 2020.

It stopped airing shows for a few weeks following the landfall of Cyclone Amphan and resumed streaming after electricity and connectivity were restored in Kolkata.

[2][8][9] The target audience consists of Bengalis including its international diaspora, attracting listeners from places like London and the United States.

[11] One of the popular segments of the station was Quarantine Diaries, which featured a daily news summary and included analysis of the controversial Citizenship Amendment Act and the associated National Register of Citizens amid the pandemic.

[10][9] Recorded performances were crowdsourced from listener contributors,[1] which were accepted based on a day's specified criterion and included experiences of individuals isolated in their homes.

The episodes include educational content related to science and technology in simplified language for the understanding of untrained adults and children.