After the Romanian Revolution of 1989, Vasile was elected (with student support)[citation needed] Vice Dean of the Faculty of Commerce at ASE, a position he held until 1992.

In terms of foreign policy, Radu Vasile also had an important activity, being a founding member of the Central European Forum, along with Raymond Barre (former Prime Minister of France), Helmut Schmidt (former Chancellor of Germany), and others.

He lectured on Romanian history at the "Doctoral Schools" at the Sorbonne and gave over 50 scientific papers at academic sessions in the country and abroad.

Radu Vasile was a senator in the 1992–1996, 1996–2000, and 2000–2004 legislatures, last time elected on the lists of the Democratic Party (PD); he was a member of the parliamentary friendship groups with Lebanon and UNESCO.

As Prime Minister, he was confronted with the Mineriad of February 1999 which his government solved (along with former President Emil Constantinescu) by the so-called Peace of Cozia.