She is best known for her research of the human impact on the behavior of black bears in Montana and is an advocate for women and people of color in the sciences.
She says that, as a child, she spent time watching television shows about wildlife and conservation which inspired her interest in ecology.
As a National Geographic Society fellow, she worked with the American Prairie to predict which human habitats will attract bears as part of the reserve's restoration efforts in northeast Montana.
Wynn-Grant used camera traps,[4] geographic information systems and other research methods to study the movements of bears to better understand their habitat preferences and risk of being struck by vehicles or euthanized by local authorities.
[5] From April to July 2021, Wynn-Grant hosted Crash Course Zoology, a fourteen-episode series on YouTube which focuses on different aspects of animal biology.