By 1816 he returned to Florence with his family, and in 1817 established himself in a country residence near Figline, where he passed a dozen years in the study of the natural sciences, agriculture and political economy.
By 1827, along with Cosimo Ridolfi, Lapo de' Ricci, and Gino Capponi, they began publication of the Giornale Agrario Toscano (Tuscan Journal of Agriculture).
In 1847, he moves to Florence, and along with Bettino Ricasoli and Vincenzo Salvagnoli, he publishes a pro-Italian nation journal La Patria.
His politics mixed loyalties to an Italian nation-state with a neo-guelph dedication; he aspired that there could be a more concordance between the Roman Catholic church and the rising liberal and nationalistic forces in the country.
This prompted Lambruschini to return to politics, becoming vice-president of the Consulta di Stato and deputy to the Tuscan Assembly and in 1861 to the Italian Senate.