He completed his pathology residency at Johns Hopkins, and then spent one year as a fellow at the Memorial Sloan Kettering Cancer Center in New York City.
[3] He has researched the characterization of PanINs, the precursor lesions that give rise to invasive pancreatic cancer.
[2] Hruban was Director of Science for the Lustgarten Foundation for Pancreatic Cancer Research, and Chair of the advisory committee for the Alan Mason Chesney Medical Archives, the official repository of Johns Hopkins University.
[2] He was also involved in the large-scale project of creating world's first virtually complete draft map of human proteome led by the Institute of Bioinformatics, Bangalore, India and the Johns Hopkins University.
[7] He also produced an award winning documentary on the life of William Stewart Halsted, the founding head of surgery at Johns Hopkins.