Ramon Santana is a municipality (municipio) of the San Pedro de Macorís province in the Dominican Republic.

The Guasa river, a tributary of the Soco, is close to the town.

In 1888, it was made a Puesto Cantonal (a "military post"), similar to the present Municipal district, of the El Seibo province.

In 1938, Ramón Santana was transferred to the San Pedro de Macorís province as a municipality.

This Dominican Republic location article is a stub.