The fifth generation Ram was introduced in January 2018 at the North American International Auto Show in Detroit, Michigan as a 2019 model year.

The fourth-generation (DS) continued to be produced through the 2024 model year and was sold alongside the fifth-generation as a lower-priced option (dubbed "Classic").

Its design is more basic than other trim levels, with halogen headlamps, incandescent taillamps, and a black plastic grille.

The HFE is only available with the V6 engine with the eTorque hybrid system (except with the 2021–2022 models which were also available with the EcoDiesel), the most economical rear axle ratio, 20-inch wheels with low rolling resistance tires, a smaller 23-US-gallon (87 L; 19 imp gal) fuel tank, and in a 4×2 configuration (reducing weight).

The North Edition adds off-road oriented features, such as Hill Descent Control and Tow Hooks, combined with body color bumpers, mirrors, and grille.

With this special edition comes the Uconnect 4 8.4 touchscreen, 7-inch digital cluster display, dual zone climate control, and heated front seats and steering wheel.

[3] The off-road oriented trim level, the Rebel offers an electronic locking rear differential, 33-inch tires, and tow hooks.

[1] The Sport is a Canadian-only trim level that offers a sportier look in addition to a standard Uconnect 4 8.4-inch touchscreen, 7-inch digital cluster display, and heated front seats.

However, for the fifth generation, the engine is now equipped with the "eTorque" belted alternator starter system, a type of mild hybrid.

[5] Energy is stored in 0.43 kWh, 48 V lithium-ion battery mounted inside the passenger cabin on the rear wall between seats and pickup bed.

[6] An upgrade is available to the 5.7-liter (350 cu in) Chrysler Hemi, a V8 engine, which produces 395 horsepower (295 kW) and 410 pound force-feet (556 N⋅m) of torque.

The Hemi V8 is also available (mandatory for the 2023 and Present model years) with slightly more powerful eTorque system with a motor–generator supplied by Magneti Marelli adding 16 hp (12 kW) and 49 lb⋅ft (66 N⋅m) of torque to the belt which multiplies it to create 130 lb⋅ft (176 N⋅m) of assist.

[7] For the 2019 through Present model years, an upgrade is available to the 3.0-liter (180 cu in) EcoDiesel, a turbocharged diesel V6 engine, which produces 260 horsepower (194 kW) and 480 pound force-feet (651 N⋅m) of torque.

In addition, the Ram 1500 features active front grille shutters, which are now driver-adjustable, as well as a lower drag coefficient for improved aerodynamic performance.

ЛйСЭ The Ram 1500 offers a choice of four different in-car entertainment systems, dependent upon the trim level chosen: The base Uconnect 3 5.0BT system, standard on Big Horn/Lone Star and optional on Tradesman, includes a five-inch touchscreen display, AM/FM radio, Bluetooth with hands-free calling and wireless audio streaming, USB and auxiliary inputs, a rearview backup camera display, and integrated digital compass.

The mid-level Uconnect 4 8.4 system, standard on Rebel, Laramie and optional on Big Horn/Lone Star, adds the following features to the Uconnect 3 5.0BT system: an 8.4-inch touchscreen display, Apple CarPlay and Android Auto integration, and a USB-C input that supports USB fast charging.

In addition, Ram has released a line of special-edition (RED)-themed merchandise, including coolers, plaid shirts, work gloves, and T-shirts.

[10] The 2022 Ram was tested by the Insurance Institute for Highway Safety (IIHS), and the top trim of the Crew Cab version received a Top Safety Pick award: The Ram 1500 received multiple industry awards even before its availability to customers.