[1][2] Ghosh was one of the personalities who helped John Elliot Drinkwater Bethune establish a girls' school in Calcutta.

[3] Ramgopal Ghosh received his early education at the Hare Preparatory school and joined the Hindu College in 1824 where he studied under Henry Louis Vivian Derozio.

In 1846, he opened a trading firm in his own name, styled R. G. Ghose & Co. Ramgopal Ghosh was one of the earliest public agitators in Bengal.

For some time he was the editor of this paper, and when it ceased to exist, he started another called the Spectator and later the Durpan.

In 1861, he was nominated as a member of the Bengal Legislative Council, but could not join owing to failing health.