The score was recorded at the MGM Scoring Stage in Culver City, California with the Hollywood Studio Symphony conducted by Nicholas Dodd,[1] together with the African Children's Choir conducted by Jasper Randall.

Rampage marks the fourth collaboration between Andrew Lockington and Brad Peyton.

The pair had previously worked on Journey 2: The Mysterious Island, San Andreas and Incarnate.

For the basis of the score, Andrew recorded Howler monkeys in Costa Rica and ran them through heavy synthesizers.

The African Children's Choir was used in the film's opening space scene, Andrew had recorded them and experimented with "modular synths, remodulators and a unison carrier wave" and the end result altered the choir into something very space-themed.