[2][3] American College for Girls originated as a trilingual (English, Arabic, and French) missionary school of the United Presbyterian Church of North America.

The graduates and the Egyptian friends of the college paid three quarters of the cost; at that time the highest amount donated by an individual was five hundred pounds.

In a huge celebration, headed by Dr.Martin and attended by high Authorities in the country and a large number of graduates who participated with their donations in the construction of the library.

In 1960, with the nationalization of private schooling, ownership of the college was transferred to the Evangelical Church of Egypt (Synod of the Nile), an Egyptian Protestant organization.

In 1967, following the Arab – Israel War and subsequent strained relations with the United States, the school's name was changed to Ramses College for Girls.

The school's graduates include leading figures in social development, aviation, diplomacy, government, and education, such as Aziza Hussein, Lotfia ElNadi, Aida Guindi, Hanan al-Shaykh and Nawal al-Tatawi.