It was the result of dedicated efforts by Dr.Mallavarapu Venkata Krishna Rao, who was the then Minister of Education in the cabinet of Sri Chakravarti Rajagopalachari in the composite Madras state.

Though their efforts started in 1955 the college became a reality on 2nd April 1958 in a meeting in Kakinada attended by Sri Neelam Sanjiva Reddy, the then Chief Minister of Andhra Pradesh in the house of Dr Lakkaraju Subbarao where the Maharajah of Pithapuram gave consent to start the Medical College in an orphanage building being run by him on pithapuram road kakinada.

Dr. Datla Satyanarayana Raju and Dr. Mallavarapu Venkata Krishna Rao founded and registered the Medical Education Society on 16 April 1958.[2].

Sri P.S.Raju garu , Zamindar of Goteru, donated huge amount of money and helped in establishing this medical college.

[citation needed] Rao Venkata Kumara Mahipati Surya Rau, the Maharaja of Pithapuram, leased the palatial orphanage buildings (now the Main Campus) to house the Medical College.

Their teaching work for first MBBS was initiated on 15 August 1958 by Dr. V. S. Krishna, vice chancellor of Andhra University.

Sri Draksharama Choultry Trust represented by the Pydah family gave a donation of ₹50,000 with which a lecture hall was constructed.

A medical exhibition was organised by students and staff after almost 25 years which attracted huge crowds from the beginning to the end of the event.

Several superspecialty departments are being created and their offices are being constructed in the renovated 2nd floor of the main OP building.

An ART (Anti Retroviral Therapy) center which caters to the special needs of patients affected with the HIV virus was moved to a new building.

Neonatology course was added by MCI in 2012 making it the first medical college in Andhra Pradesh and eighth in the India to provide D.M.