Bhandari is pursuing her study on signal transduction in biological systems, with particular emphasis on understanding the role of inositol pyrophosphates in physiology and metabolism.
Post her doctorate at Indian Institute of Science, Bhandari worked with Sandhya Srikant Visweswariah on signal transduction by the membrane-bound guanylyl cyclase, GCC, which is involved in maintaining fluid and ion homeostasis across the intestinal membrane.
[2] In 2001, Bhandari joined John Kuriyan laboratory at the University of California, Berkeley as a post-doctoral fellow to work on the structural biology and biochemistry of proteins involved in cell signaling.
[2] In 2003, Bhandari relocated to the Johns Hopkins School of Medicine in Baltimore, where she worked with Solomon Snyder on deciphering the role of inositol pyrophosphates as signalling molecules.
Inadequate levels of IP7 led to reduction in another phosphate-rich molecule called polyphosphate (a long chain of phosphate groups linked to each other).