"Rattlesnake Shake" is a song by British rock group Fleetwood Mac, written by guitarist Peter Green, which first appeared on the band's 1969 album Then Play On.

[3] During a 1969 interview with Peter Green prior to the release of Then Play On, Nick Logan of New Musical Express discussed the song's subject matter as being "about a male function not mentioned in the best circles.

[7] To achieve the rustling noises heard at the end of each chorus, Green used the sounds of an actual rattlesnake found on an audio tape.

[20] Also in 1981, Bob Welch recorded a live version of the track on his album Live at The Roxy, with contributions from Stevie Nicks (tambourine), Christine McVie (maracas), Mick Fleetwood (drums), Robbie Patton (cowbell), Alvin Taylor (guitar), Robin Sylvester (bass), Joey Brasler (guitar), and David Adelstein (keyboards).

[22] Steven Tyler of Aerosmith recalled that he had seen one of Joe Perry's bands in the 1960s cover the song, which he partially attributed to their eventual musical partnership.

A recording from the show later appeared on the Celebrate the Music of Peter Green and the Early Years of Fleetwood Mac live album.

McVie initiated the collaboration by calling Fleetwood, which prompted him and Vito to bring a piano to her hotel suite so she could practice the material.

"Rattlesnake Shake" was one of the four songs McVie played with the Mick Fleetwood Blues Band, with the others being "Get Like You Used to Be", "World Turning" and "Don't Stop.