He is the Herman P. Schwan Chair of Bioengineering as well as a professor in the Department of Chemical and Biomolecular Engineering at the University of Pennsylvania.
[1] Radhakrishnan's work is centered around creating digital models for biomedical engineering applications, particularly in cancer treatment and nanomedicine.
The paper used transition path sampling to uncover the atomic and energetic details of the conformational changes in DNA polymerase β that precede nucleotide incorporation, identified key residues and cooperative dynamics crucial for the enzyme's function and fidelity, and provided a protocol applicable to other biomolecular reactions.
[5] His 2006 collaborative study with C Alba-Simionesco investigated how confinement within various porous materials influenced the freezing, melting, and structural properties of adsorbates, highlighting new surface-driven and confinement-driven phases, as well as the effects on the glass transition.
[6] Radhakrishnan's 2010 paper investigated ErbB3/HER3 kinase activity, revealing its capacity for autophosphorylation and ATP binding despite structural differences, suggesting its role in signaling pathways and its potential as a therapeutic target in cancer.