It is located in the Diocese of Rapid City and serves Oglala Lakota Native American children on the Pine Ridge Indian Reservation.

[2] This campus includes Red Cloud Elementary School (Lakota: Maȟpíya Lúta Hukhúčiyela Owáyawa and Red Cloud High School (Lakota: Maȟpíya Lúta Waŋkáwapȟaya Owáyawa).

[4] The Jesuits and Sisters of St. Francis of Penance and Christian Charity founded the institution at the request of Chief Red Cloud.

All of the bricks for the building were made from local clay and lime on the grounds of what is today Red Cloud Indian School's Pine Ridge campus.

[7] In 1969, Holy Rosary Mission was officially renamed Red Cloud Indian School, both as a token of respect for the man whose work had made the school possible and as part of a program of re-identification to emphasize its native-American roots over cultural imperialism, and the lasting bond between groups from two separate cultures who wanted to enhance the best parts of both worlds to serve the people of the Pine Ridge Indian Reservation.