For almost its entire length, it drains the northern Highland Rim of Tennessee and the adjacent (and analogous) Pennyroyal Plateau of Kentucky.

Crossing the state line into Robertson County, the Red continues to flow primarily westward but with minor meanders.

As the area drained by the Red River becomes somewhat less agricultural and more of the remaining farmers switch to techniques involving less cultivation, it is likely that this color will continue to lessen in intensity, but certainly will not vanish.

This meeting house was the site of one of the early revivals of the Second Great Awakening, a religious movement that swept over the United States near the turn of the 19th century.

A place of interest is the Bell Witch Cave, which is located on the left-hand side of the river.