It is 3–4 in (117 mm) in length from nose to tail as a full adult, and pale grey to yellow-brown or reddish in color, topped with dark blotches alongside the body and back.

[4] This lizard can be found across southeastern Arizona and along the transition of the southern zone of the central mountains region.

[5] This horned lizard occupies primarily level or gently sloping terrain with openly spaced desert vegetation such as mesquite, creosote bush, and saguaro cactus.

[3] It can be found primarily in a hot and dry climate where the ground may be covered in limestone dust.

They tend to be sedentary creatures which is reflected in their morphology (often displaying matching color patterns to their environment as camouflage).

Regal horned lizards generally stay in an open habitat with access to burrows to avoid predators and high temperatures.

Though they have spikes all around their body, their main defense when coming in contact with predators is the ability to squirt blood from their eyes.

[10] Regal horned lizards are oviparous and reproduce via sexual reproduction (specifically internal fertilization).

Males tend to exhibit enlarged reproductive organs (testes, vasa deferentia, and hemipenes) when in preparation for mating.