The original Regents Park station opened on 11 November 1912 when a line was built from Lidcombe.

Until it closed in April 1966, Regents Park was the junction for a line to Potts Hill Reservoir and sidings serving an industrial complex to the north-west of the station.

[6][8] Regents Park Station held a celebration for the centenary of the Lidcombe to Cabramatta railway on 14 October 2024 with Sydney Trains staff, Member for Auburn Lynda Voltz, and local residents.

[9][10] Historically, Regents Park was served by services from the city and Lidcombe operating to Bankstown and Liverpool on an alternate basis.

Transit Systems NSW operates two bus routes via Regents Park station, under contract to Transport for NSW: Regents Park station is served by one NightRide route: