Hudlin worked as a producer on the 2012 film Django Unchained, directed by Quentin Tarantino, which received an Academy Award nomination for Best Picture.

Their great uncle was tennis instructor Richard A. Hudlin, who mentored Arthur Ashe and Althea Gibson.

[12] After college, Hudlin and his brother formed a production company and made music videos for such artists as Heavy D, Jamaica Boys, and others.

[13][14] Hudlin directed—with older brother Warrington producing—his first feature-length film, 1990's low-budget teen hip-hop comedy House Party, which starred Kid 'n Play.

The film was a big-budget romantic comedy that starred Eddie Murphy, who had a term deal at Paramount Pictures and hired the Hudlin Brothers because he liked House Party.

It starred an all-black cast that included Robin Givens, Halle Berry, Martin Lawrence, David Alan Grier, and Chris Rock.

[13][17] Boomerang was based on an original idea by Murphy and was written by Saturday Night Live writers Barry W. Blaustein and David Sheffield.

[18] A celebration of the 25th anniversary of Boomerang's release was held on July 1, 2017, at the National Museum of African American History and Culture in Washington, D.C., with a conversation between Hudlin and producer George Alexander.

[19][20] In 1992, while making Boomerang, Hudlin wrote the animated film, Bebe's Kids, which was championed by Paramount's Brandon Tartikoff, and was made in memory of comedian Robin Harris, who had died in 1990.

[citation needed] Hudlin was a producer of Quentin Tarantino's Django Unchained, starring Jamie Foxx, Leonardo DiCaprio, Christoph Waltz, Kerry Washington, and Samuel L. Jackson.

[33] On July 12, 2021, it was announced that Hudlin along with Ian Stewart will the executive producers for the 73rd Emmy Awards which will have a live audience on September 19, 2021, on CBS.

[39] In 2013, Chrisette Hudlin set up Emhoff on a blind date with then-Attorney General of California and former Vice-President, Kamala Harris.