Regina was born in Autun, France, to a pagan named Clement.

Her mother died at her birth and her father placed her with a Christian nurse who baptized her.

At the age of fifteen, she was betrothed to the proconsul Olybrius, but refused to renounce her faith to marry him, for which she was tortured and was beheaded at Alesia in the diocese of Autun,[3] called Alise-Sainte-Reine after her.

Her martyrdom is considered to have occurred either during the persecution of Decius, in 251, or under Maximian in 286.

[3] Honored in many Martyrologies, Regina's feast is celebrated on 7 September[2][4] or in the Archdiocese of Paderborn on 20 June.