Regina was born in Autun, France, to a pagan named Clement.

Her mother died at her birth and her father placed her with a Christian nurse who baptized her.

[2] She communed with God in prayer and meditated on the lives of the saints.

At the age of fifteen, she was betrothed to the proconsul Olybrius, but refused to renounce her faith to marry him, for which she was tortured and was beheaded at Alesia in the diocese of Autun,[3] called Alise-Sainte-Reine after her.

[3] Honored in many Martyrologies, Regina's feast is celebrated on 7 September[2][4] or in the Archdiocese of Paderborn on 20 June.