An important event in the system's history was a fire in its "bus barn" on January 23, 1949, that destroyed 17 trolley coaches, nine gasoline buses, five steel streetcars and nine wooden cars.

Since 1955, its preferred transit fleet has been buses because their freedom from overhead lines makes them suitable for detours and charters.

An innovation in the early 1970s was its Telebus service, which used a telephone/radio dispatching system to send buses to individual homes.

[1] In 2008 Regina Transit adopted three new express route centred on the university, cutting bus trip time by up to 20 minutes.

[8] Regina Transit's fleet consists mostly of Nova Buses, with a few Vicinity operating on less-busy routes.

Regina Transit Services has been working with the Saskatchewan Human Rights Commission to improve accessibility and inclusivity of public transportation since 2013.

Part of that work includes the introduction of low-floor accessible buses and installation of audible stop announcements.