In 2004, she gained national prominence when she was hired as the presenter of the first phase of Casos de Família, in SBT.

[3] On July 28, 2011, she signed a contract with RedeTV!, where she presented Manhã Maior alongside Daniela Albuquerque until 2012.

In 2016, the journalist created a YouTube channel entitled Regina Volpato, where she publishes the weekly segment "Prazer, eu sou", where she interviews authentic, original, nonconformist, humorous, audacious people; who have achieved or are dedicated to the pursuit of empowerment.

[5][6] In December 2017, she was hired by TV Gazeta to cover Catia Fonseca's vacation from the Mulheres program from January 8, 2018.

[7] In February, due to Catia's move to Band and also to the good results she obtained in charge of the attraction during her provisional contract, Regina was officially made effective as the titular presenter of Mulheres.