[3] Reginaldo de Lizárraga was born in Lizarraga, Spain and ordained a priest in the Order of Preachers.
[4][5] On 31 August 1598, he was confirmed by Pope Clement VIII as Bishop of Concepción and installed in December 1602.
[3][4][5] On 24 October 1599, he was consecrated bishop by Toribio Alfonso de Mogrovejo, Archbishop of Lima.
[4][5] On 20 July 1609, he was appointed during the papacy of Pope Paul V as Bishop of Paraguay.
[1][4][5] He served as Bishop of Paraguay until his death on 10 November 1609.