[5] Since turning professional, Prograis has fought at Barclays Center in Brooklyn, New York, on the undercard of the Keith Thurman vs. Shawn Porter fight, which was the first primetime boxing event televised on CBS in over 40 years.
[10] Prograis faced the WBA super lightweight champion Kiryl Relikh in the tournament semifinals, which took place at the Cajundome in Lafayette, Louisiana on April 27, 2019.
[13] In the final, which took place on October 26, 2019, at The O2 Arena in London, England, Prograis faced the IBF and The Ring super lightweight champion Josh Taylor.
[16] Prograis faced the unbeaten Juan Heraldez on October 31, 2020, on the undercard of the Gervonta Davis and Leo Santa Cruz Showtime pay-per-view.
Prograis dropped his opponent with a straight left early in the final round of the bout and finished him with a flurry of punches at the 1:23 minute mark.
The fight was stopped in the sixth round, due to an accidental low blow that rendered Redkach unable to continue competing.
The result was immediately overturned however, as Georgia regulations state that a boxer who is unable to continue after being hit with an unintentional low blow shall be declared the loser by a technical knockout.
[25] Prograis was expected to make his first WBC light welterweight title defense against Liam Paro in the main event of a DAZN broadcast card, which will take place on June 17, 2023, at the Smoothie King Center in New Orleans, Louisiana.
[29] On July 28, 2023, ESPN reported that Prograis would make his second WBC title defense against then-undisputed lightweight world champion Devin Haney.
[30] The WBC granted them permission to pursue the fight on August 1, 2023, although the sanctioning body’s Board of Governors was split in their vote.
[33] Regis Prograis was scheduled to face Jack Catterall in a 12-round junior welterweight bout at Co-op Live Arena in Manchester, England on August 24, 2024.