[3] It is composed of an extracellular matrix that includes laminin, type IV collagen, and nidogen, and is secreted by embryonic cells in the distal parietal endoderm.
This space provides protection to the embryo from varying uterine pressures exerted by smooth muscle contractions of the myometrium.
During post gastrulation Reichert's membrane is necessary for the maternofetal exchange of nutrients.
[2] A major difference in the early formation of the mouse embryo, and that of the human embryo is that in the mouse following implantation the epiblast takes on an egg or cylindrical shape; in the human the epiblast forms into a horizontal, disc-shape the bilaminar disc.
A study that looked at this morphological difference between a human embryo initial development and a mouse embryo, concluded that it is likely that Reichert's membrane is the key regulator of the epiblast's horizontal growth.