Reine Flachot arrived in France at the age of twelve when her French parents returned home.
There, she began her studies with Jean Dumont and then, in 1935, entered the Conservatoire de Paris in the class of Gérard Hekking.
There followed a career that made her the ambassador of the "French school of cello for sixty years" (Christine Heurtefeux) all over the world, with a strong activity between the end of the 1950s and the beginning of the 1970s, a period from which she devoted much time to the transmission of her knowledge.
She stayed there until 1974, when she joined the City of Basel Music Academy, while continuing her studies at the ENM in Paris and becoming the first woman named cello teacher (CNSM de Lyon).
She was then 73 years old and ended a career having led her to choose with restraint her discographic production (4 recordings).