Siegmund-Schultze studied mathematics at the Martin Luther University Halle-Wittenberg, where he received his doctorate in 1979 on the history of functional analysis.
He then worked until 1990 as an assistant at the Humboldt University of Berlin, where he completed his habilitation in 1987 ("Contributions to the analysis of the development conditions of mathematics in fascist Germany with special consideration of the reviewing system").
[2][3] From 1991 to 1994 he was a Feodor Lynen research fellow at the Alexander von Humboldt Foundation in the USA.
[2] Siegmund-Schultze is known for historical work on the unfortunate circumstances and emigration of mathematicians from National Socialist Germany.
[15] In 2014 at the ICM in Seoul, he was an invited speaker with talk One hundred years after the Great War (1914–2014): A century of breakdowns, resumptions and fundamental changes in international mathematical communication.