A sequel to Remnant: From the Ashes, the game was released for PlayStation 5, Windows and Xbox Series X/S on July 25, 2023.

[5] For the Handler class, the prime perk ability is "Bonded", which allows their dog companion to revive the character after they have fallen in combat.

[6] While the first game features procedural generation by changing a level's layout and enemy spawn points, it has been significantly expanded in Remnant 2.

[8] The game's story follows a nameless survivor dubbed ''Traveler'' who is surviving on the road with their friend Cass, who is suffering from an infection caused by the root, a destructive plant-like species that spreads like a virus.

During your travels, the two are ambushed by the Root and nearly killed, but at the last minute, they are saved by Clementine (subject 2923) and taken to Ward 13, where the survivors now live outside the bunker.

While Cass is being treated for her Root sickness, the Traveler meets with Andrew Ford, the founder of Ward 13, who takes him into the bunker of Ward 13, where he reveals and activates a dormant World Stone, a red crystal that acts as a portal to other realms, and his plan to destroy the Root.

The Keeper explained reluctantly that there are only two options left: either let the Root corrupt the world, or reset the universe.

Explaining the system, David Adams, CEO of Gunfire Games, added that "at the top level we randomly generate the order of the biomes" that a player may encounter.

The system will then generate "one of two unique storylines" in each biomes, and "all the mini bosses, side quests, events" within it.

[12] The game's first downloadable content (DLC) pack, titled The Awakened King, was released on November 14, 2023; it features two additional songs by Trivium's Matt Heafy.

[34] The sales of the game exceeded Gearbox's expectations, selling over 1 million units during its first week after launch.