Taking place before the first Darksiders game, the player controls Fury, one of the Four Horsemen of the Apocalypse, in her quest to capture the seven deadly sins which have taken corporeal form and escaped imprisonment.

Darksiders III received mixed reviews from critics, who highlighted the technical issues and bugs on both PC and console versions, as well as the too simplistic combat and puzzle systems.

[5][6] Fury can take on multiple different elemental forms in order to enhance her combat capabilities by granting her new weapons, attacks and traversal abilities.

The combat is described as more methodical[4] and straight forward,[7] not focusing on large crowds of enemies like the previous games and removing the hit counter.

Similar to War, yet dissimilar to Death, Fury collects souls from enemies and from objects in the environment, as a form of currency or an expendable resource.

[8] The game takes place in a continuous environment where exploration plays a large role in gathering more lurchers and materials to upgrade Fury herself and her arsenal.

She claims one of her talismans and uses it as a prison to hold Envy before venturing to a sanctuary named Haven, where she encounters Ulthane, a member of the Maker race, and some humans who survived the Apocalypse.

A portal opens up below her and takes her to the Lord of the Hollows, a powerful entity with the ability to release other beings from the cycle of life, death and rebirth in the Well of Souls.

Returning Abraxis' soul to the Lord makes him reveal that he was once part of the Charred Council but left over disagreements on how to enforce the Balance since the Kingdom of Man was ignored among the fights of Heaven and Hell.

Eventually Fury confronts and defeats the final Sin, Pride who reveals that the Council have been secretly betraying the Balance behind everyone's backs from the start.

At this point, the Watcher reveals herself to be the real Envy, having tricked Fury and the Council to strengthen herself by absorbing the rest of the sins into her amulet, gaining their powers.

She then reveals her acquisition of the Hollow Lord's gift to the maker, who is awestruck at the sight of it, but refuses when offered the relic out of shame for past misdeeds, before Fury travels to the Council chamber and defeats Envy.

Returning to Earth, Fury helps the Makers to defend the humans' escaping through the Reflecting Pool to another realm while demons attack Haven.

[2][4] Eurogamer's review criticized the "straight forward combat" saying it is a matter of "upgrade weapon damage" and that the few puzzles are too simple, and in concluding that it "has done better in the past".