Renal compensation

Renal compensation is a mechanism by which the kidneys can regulate the plasma pH.

It is slower than respiratory compensation, but has a greater ability to restore normal values.

[3] The renal compensation process usually takes a few days to complete as it is dependent upon changes in the reabsorption of bicarbonate.

[citation needed] In respiratory acidosis, the kidney produces and excretes ammonium (NH4+) and monophosphate, generating bicarbonate in the process while clearing acid.

There is also an excretion of Cl- and a reabsorption of sodium, resulting in a negative urinary anion gap.