Rene Mandri (born 20 January 1984 in Jõgeva) is an Estonian former professional road bicycle racer, who competed as a professional between 2006 and 2012, with the Auber 93, Ag2r–La Mondiale and Endura Racing teams.

He had a life-threatening crash in 2008 Giro d'Italia Stage 6.

He has been working as cycling coach since 2014 and he is a recognized Sports Organisation Leader in Estonia with an IOC diploma.

He now works as a directeur sportif for UCI ProTeam Israel–Premier Tech.

This biographical article relating to Estonian cycling is a stub.