12663820129ENSG00000215853ENSMUSG00000041984Q6XPR3P97347NM_152364NM_001122965NM_009100NP_001116437NP_033126Repetin is an extracellular matrix protein expressed in the epidermis.

Repetin is part of the S100 fused-type protein family and contains an EF hand structural domain.

It functions in the cornified cell envelope formation.

RPTN is one of the genes that differ between present-day humans and Neanderthals.

[5] RPTN helps protect skin cells, and since the Neanderthals were missing this protein, the Neanderthals were better adapted to the cold, but less so to disease.