[1] Artists currently signed to Reprise Records include Green Day, Enya, Michael Bublé, Eric Clapton, Stevie Nicks, Neil Young,[a] Deftones, Mastodon, Lindsey Buckingham, Josh Groban, Disturbed, Idina Menzel, My Chemical Romance, Gerard Way, Dwight Yoakam, Never Shout Never, and Billy Strings.

As CEO of Reprise, Sinatra recruited several artists for the fledgling label, such as fellow Rat Pack members Dean Martin and Sammy Davis Jr.

The original roster from 1961 to 1963 included Bing Crosby, Jo Stafford, Rosemary Clooney, Duke Ellington, Nancy Sinatra, Esquivel and stand-up comedian Redd Foxx.

One of the label's founding principles under Sinatra's leadership was that each artist would have full creative freedom, and at some point complete ownership of their work, including publishing rights.

In August 1963, as part of a film deal, Warner Bros. purchased Reprise (which had been losing money) from Frank Sinatra, who nonetheless retained a 1/3 interest in the label.

Through direct signings or distribution deals, by the 1970s the Reprise roster grew to include Lee Hazlewood, Jill Jackson, Jimi Hendrix, the early Joni Mitchell recordings, Neil Young, the Electric Prunes, Donna Loren, Arlo Guthrie, Norman Greenbaum, Tom Lehrer, Kenny Rogers and The First Edition, Tiny Tim, Ry Cooder, Captain Beefheart, John Sebastian, Family, the early 1970s recordings by Frank Zappa and the Mothers, Gram Parsons, Emmylou Harris, Nico's Desertshore, the Fugs, Jethro Tull, Pentangle, T. Rex, the Meters, John Cale, Gordon Lightfoot, Michael Franks, Richard Pryor, Al Jarreau, Fleetwood Mac, Fanny, and the Beach Boys.

As of 2017, it is home to such artists as Enya, Michael Bublé, Eric Clapton, Green Day, Stevie Nicks, Neil Young, Deftones, Josh Groban, Disturbed, Idina Menzel, Tom Petty and the Heartbreakers, Gerard Way and Never Shout Never.