The Reserva Provincial La Payunia (Spanish: La Payunia Provincial Reserve) also known as Payún or Payén is a natural reserve located in the Malargüe Department in the southern part of Mendoza Province, Argentina, about 160 km away from Malargüe city.

La Payunia is home to the many volcanic cones, being noteworthy the Payún Matrú volcano.

The flora is represented by matorrales, prairies, native mountain species and other typical patagonian plants such as Adesmia pinifolia, Festuca pallescens, Grindelia chiloensis, Ephedra ochreata miers, Neosparton ephedroides grisebach, Psila spartioides, Prosopis denudans (between 500 and 1,300 m AMSL) and Schinus poligamun and Larrea nítida cavanilles (between 1,800 and 2,850 m AMSL).

[1] Other mammals include a large rodent, the plains viscacha Lagostomus maximus, and the largest native animal on the reserve, the guanaco Lama guanicoe.

[2] The annual round up is monitored by the Wildlife Conservation Society, and wool and yarn are exported abroad.