The area where Resistencia lies was the site of the Guaycuru peoples, pedestrian tribes that live on hunting and fishing.

Resistencia was founded on January 27, 1878, the date on which the initial measurement was approved (executed by Arturo Seelstrang) and officially created.

The initial colonization process was the result of an official policy of settlement of this region based on Immigration Law No.

The public transport service Resistencia-Barranqueras was created, along with numerous buildings for schools, police stations, municipalities and health centers.

Resistencia is one of the warmest cities in Argentina, and is known for its extremely hot, humid summer weather with frequent lightning.

The transition to autumn is slow: March's temperatures are very similar to midsummer, and April is still warm with an average high of 26.2 °C (79.2 °F) and a low of 17.0 °C (62.6 °F), and rainfall is very abundant: 284.9 millimetres (11 in) during that month.

[7] The city's economy, originally based on agriculture and trade, has diversified into the service sector in recent decades.

Resistencia is known nationally as the "city of sculptures" and "open-air museum" because of the more than 500 monuments and other works of art spread among its streets.

The city has been served by Resistencia International Airport since 1965; its terminal, completed in 1971, was designed by renowned modernist architect Amancio Williams.