[4][5] Along with Judge M. K. Sharma, she also dismissed a plea from the Government of India to prevent the removal of illegal constructions in and around Ministers' residences, ordering them to be demolished.
[9][10] In 2009, she granted bail to BJP politician Varun Gandhi in a case filed against him for making provocative speeches concerning religion, while the Bharatiya Janata Party disassociated themselves with him.
[11] In 2016, along with Judge Pratibha Rani, she upheld the sentence of the death penalty to the four adult convicts in the 2012 Delhi gangrape and murder case.
[13][14] While a High Court judge, Khetrapal was instrumental in establishing a scheme to provide financial aid for children whose parents are incarcerated.
[17] She is also conducting ongoing proceedings into a complaint regarding corruption, filed by Delhi BJP leader Manoj Tiwari against Aam Aadmi Party ministers Manish Sisodia and Satyender Jain.